Minimal metabolism allowing Candida yeast to be pathogenic to humans
Yeast-macrophage interaction, lipid metabolism, neoglucogenesis.
Candida lusitaniae
Intra-macrophagic surviving yeasts (blue cells)
- Whole proteome analysis of intra-macrophagic surviving yeasts by mass spectrometry
- Identification of proteins and metabolic pathways up- and down expressed in our annotated genome database
- Highlighting the major role of yeast lipid metabolism for intra-macrophagic survival
- Identification of several fatty acids catabolism pathways in Candida, involving or not involving Fox2p, the main enzyme of fatty acid beta-oxidation in yeasts
- Demonstration for the first time in ascomycetous yeast that Fox2p can localize both in peroxisomes and mitochondria.
- The movie was shot in the BIC studios at Bordeaux University
- Executive producer: El-Kirat-Chatel Sofiane
- Associate producer: Dementhon Karine
- Senior Direction production: Noël Thierry
Starring C. lusitaniae and macrophages
C. lusitaniae, alias the "bad" cell and Macrophages, alias the "good" cells respectively
[clic here to see a video of a macrophage engulphing a Candida yeast cell]
Immunoelectron microscopy showing Fox2p localizing both in peroxysomes (P) and mitochondria (M)